CV-1 (Cercopithecus aethiops-1) is a cell line derived from the kidney of an African green monkey (Cercopithecus aethiops), which is often used in scientific research. It was established in the 1960s and has since been employed in various studies, including virology, molecular biology, and cancer research.

CV-1 cells are particularly useful for the study of viruses and virus-host interactions. They are highly permissive to a wide range of viruses, such as simian virus 40 (SV40), adenoviruses, and other viral pathogens. Researchers often use CV-1 cells to isolate, propagate, and study the biology of viruses, as well as to test antiviral compounds and vaccine candidates.

CV-1 cells, along with other African green monkey kidney cell lines like Vero cells, have been instrumental in advancing our understanding of viral infections and contributing to the development of vaccines for various diseases. However, the use of non-human primate cells in research raises ethical concerns, and efforts are being made to find alternative methods or cell lines to replace their use.